The effects of hand-size variations and gender on mobile phone users’ texting satisfaction were investigated using structured questionnaire interviews with 110 subjects (18–23 years old). Focus was on text entry factors: speed, learnability, simplicity, navigation and special characters. Gender effect is significant for speed and special characters selection, with females being more satisfied than males. Hand-size effect is significant for speed, special character selections and navigation, with smaller hand-sized subjects being more satisfied than larger hand-sized subjects. Interaction effect of hand-size x gender was found to be significant for speed and special character selections. Gender, hand-size and hand-size x gender significantly affect subjects’ overall texting satisfaction, with smaller hand-sized subjects being more satisfied than larger hand-sized subjects, regardless of their gender. It was recommended that an improved or new text entry mechanism would increase texting satisfaction, regardless of their gender and hand-sizes. Results confirm that gender and hand-size variations affect users’ texting satisfaction, with regards to the text entry factors.