In this paper, we propose a novel smart framing scheduling scheme to improve energy efficiency for CSMA/TDMA hybrid MAC designs of wireless sensor network. This hybrid MAC combines CSMA and TDMA functionalities together, while obviates their shortcomings. Usually, in a hybrid CSMA/TDMA design, all the receivers have to perform low power listening all the time to wait for in-coming data. Although low power listening scheme can achieve energy saving by reducing idle listening to some extent, it is much more beneficial with a scheduling scheme to smartly turn off the radio when the receiver does not receive any data. By introducing a frame scheduling slot, all the nodes will know the neighbors’ behavior in the upcoming slots. After the time slot assignment, senders advertise their traffic schedules to let neighbor nodes know which one will receive data, and what the amount of the data is. Since each node knows exactly the schedule of other neighbor nodes, it can sleep smartly when it has received all the data and does not have other task during this round. Our simulations have shown that such scheme of smart frame scheduling has achieved significant energy efficiency.